Jayadev Suman, Steinbart Ellen J, Chi Yueh-Yun, Kukull Walter A, Schellenberg Gerard D, Bird Thomas D
Department of Neurology, University of Washington, Seattle, USA.
Arch Neurol. 2008 Mar;65(3):373-8. doi: 10.1001/archneurol.2007.61.
There is limited information regarding children's risk of Alzheimer disease (AD) if both parents are affected.
To determine the risk of AD in families in which both parents have AD.
Retrospective study.
University research center.
A total of 111 families in which both parents had a clinical diagnosis of AD. Main Outcome Measure Frequency of AD in the children of spouses with AD.
The 111 couples with AD had 297 children surviving to adulthood; 22.6% of these adult children have developed AD. The risk of AD in these children increases with age, being 31.0% (58 of 187) in those older than 60 years and 41.8% (41 of 98) in those older than 70 years. Many children (79.0%) at risk in these families are still younger than 70 years, meaning that the occurrence of AD will increase in the coming years. A family history of AD beyond the parents did not change the risk of AD in the children but did reduce the median age at onset in affected children. The apolipoprotein E epsilon4 allele played an important part in this phenomenon but did not explain all cases of AD in the children.
When both parents have AD, there is an increased risk of AD in their children beyond that of the general population. The role of family history and the specific genes involved in this phenomenon require a better definition.
关于双亲均患阿尔茨海默病（AD）时子女患该病的风险，相关信息有限。
确定双亲均患AD的家庭中子女患AD的风险。
回顾性研究。
大学研究中心。
总共111个家庭，双亲均有AD的临床诊断。主要观察指标：患AD配偶的子女中AD的发生频率。
111对患AD的夫妇有297名子女存活至成年；这些成年子女中有22.6%患了AD。这些子女患AD的风险随年龄增加，60岁以上者为31.0%（187人中的58人），70岁以上者为41.8%（98人中的41人）。这些家庭中许多有患病风险的子女（79.0%）仍不到70岁，这意味着未来几年AD的发病率将会增加。除父母外的AD家族史并未改变子女患AD的风险，但确实降低了患病子女的中位发病年龄。载脂蛋白Eε4等位基因在这一现象中起重要作用，但不能解释所有子女患AD的情况。
双亲均患AD时，其子女患AD的风险高于一般人群。家族史及参与此现象的特定基因的作用需要更明确的界定。
