Bird T D, Nemens E J, Kukull W A
Neurology Section, VA Medical Center, Seattle, WA 98108.
Ann Neurol. 1993 Sep;34(3):396-9. doi: 10.1002/ana.410340315.
Thirty-one couples in which both spouses had the clinical diagnosis of Alzheimer's disease (AD) (confirmed by autopsy in 12) were ascertained. The mean age of onset of dementia was 75.1 +/- 7.4 years. These couples had 87 children, 63 still living. Seventeen (19.5%) of the children developed dementia, with a mean age of onset of 68.9 +/- 8.3 years. Thirty of the children of the conjugal AD couples survived to age 65 or longer and 14 (47%) of them developed dementia. This prevalence of dementia in the children of affected couples is much greater than that in the children of two control groups consisting of 234 couples in which one spouse had AD and 192 couples in which neither spouse was demented. Twenty-one of the conjugal AD couples had a family history of AD but the prevalence of dementia in their children was not greater than that in the children of conjugal AD couples without a family history of AD. These results represent additional evidence of an important genetic component in late-onset AD and provide empirical risk data for the children of conjugal AD couples.
我们确定了31对夫妻，夫妻双方均有阿尔茨海默病（AD）的临床诊断（其中12例经尸检证实）。痴呆症的平均发病年龄为75.1±7.4岁。这些夫妻育有87个孩子，其中63个仍然在世。17名（19.5%）孩子患上了痴呆症，平均发病年龄为68.9±8.3岁。夫妻双方均患AD的30名孩子活到了65岁及以上，其中14名（47%）患上了痴呆症。患病夫妻的孩子中痴呆症的患病率远高于两个对照组的孩子，这两个对照组分别为：234对夫妻中有一方患AD，以及192对夫妻双方均未患痴呆症。21对夫妻双方均患AD的夫妻有AD家族史，但他们孩子中痴呆症的患病率并不高于无AD家族史的夫妻双方均患AD的夫妻的孩子。这些结果进一步证明了晚发性AD存在重要的遗传因素，并为夫妻双方均患AD的夫妻的孩子提供了经验性风险数据。
