Stoian Irina, Manolescu B, Atanasiu V, Lupescu Olivera, Buşu Carmina
Department of Biochemistry, "Carol Davila", Faculty of Medicine, University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Intern Med. 2007;45(3):305-9.
Recently discovered peptide hormone hepcidin is the key regulator of systemic iron homeostasis. Iron metabolism is regulated in response to variations in hepcidin plasma levels. Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively. The early studies showed that hypoxia, iron concentration, and inflammation influence hepcidin levels, but the exact mechanism remained elusive. Very recently, different research groups discovered that IL-6, through the Jak/STAT-3 signaling pathway, is involved in regulation of hepcidin levels in response to inflammatory stimuli. In this review we present a general view of hepcidin biology, with emphasis on regulation in inflammatory conditions.
最近发现的肽激素铁调素是全身铁稳态的关键调节因子。铁代谢根据血浆中铁调素水平的变化进行调节。铁调素水平过低或过高分别会导致铁过载或缺铁。早期研究表明，缺氧、铁浓度和炎症会影响铁调素水平，但确切机制仍不清楚。最近，不同的研究小组发现，白细胞介素-6通过Jak/STAT-3信号通路参与了炎症刺激反应中铁调素水平的调节。在这篇综述中，我们对铁调素生物学进行了概述，重点关注炎症条件下的调节。
