Rattay Frank
Institute for Analysis and Scientific Computing at the Vienna University of Technology, TU-BioMed, Wiedner Hauptstr. 8-10/101, Vienna A-1040, Austria.
IEEE Trans Biomed Eng. 2008 Mar;55(3):1122-7. doi: 10.1109/TBME.2008.915676.
The following results are based on computer simulations and on activating function analysis. In the near field, denervated muscle fibers as well as nerve fibers with a sealed ending are easier to stimulate in the central region than with electrodes close to the end. When electrode-fiber distance is increased, the electrode location for optimal stimulation efficacy shifts from a central position to a region beyond the fiber end for cathodic stimulation and to a position above the terminating part of the fiber for anodic currents. The phenomenon becomes more pronounced with increasing distance between the electrode and fiber axis, because in the far field, the current-distance relation changes from quadratic to cubic, whereas stimulation at the fiber end obeys a rather constant quadratic law.
以下结果基于计算机模拟和激活函数分析。在近场中,去神经支配的肌纤维以及具有封闭末端的神经纤维在中央区域比靠近末端放置电极时更容易被刺激。当电极与纤维的距离增加时,对于阴极刺激,实现最佳刺激效果的电极位置从中心位置转移到纤维末端之外的区域;对于阳极电流,则转移到纤维末端部分上方的位置。随着电极与纤维轴之间距离的增加,这种现象变得更加明显,因为在远场中,电流与距离的关系从二次方变为三次方,而在纤维末端进行刺激则遵循相当恒定的二次方规律。