Taniguchi T, Matsuo T, Hishikawa R, Yamaguchi A, Akato S, Shibatouge M
Department of Internal Medicine, Hyogo Prefectural Awaji Hospital, Sumoto.
Rinsho Byori. 1991 Jul;39(7):714-9.
To evaluate the diagnostic and prognostic value of PIC, we compared it with the DIC score (which is calculated from platelet count, fibrinogen, FDP, and prothrombin time). We examined 182 samples from 60 patients with coaglo-fibrinolytic abnormalities. For the diagnosis of DIC, the sensitivity of PIC was significantly higher than that of DIC score (78.46% vs 43.08%; chi 2-test p less than 0.01), although the specificity of PIC was significantly lower than that of DIC score (32.48% vs 69.23%; chi 2-test p less than 0.01). For the prediction of prognosis, the peak value of PIC and DIC score during the patient's clinical course were evaluated. The non-survivors (n = 33) had significantly higher levels of peak PIC and DIC scores than the survivors (n = 27) (peak PIC: 6.1 + 9.0 micrograms/ml vs 2.2 + 3.3, p less than 0.05; peak DIC score: 4.6 + 2.4 points vs 3.3 + 2.2, p less than 0.05). The patients with a peak PIC of more than 4.0 micrograms/ml had a mortality of over 90%. These results show that PIC is a useful diagnostic and prognostic parameter.
为评估纤溶酶抑制物（PIC）的诊断和预后价值，我们将其与弥散性血管内凝血（DIC）评分（由血小板计数、纤维蛋白原、纤维蛋白降解产物（FDP）和凝血酶原时间计算得出）进行了比较。我们检测了60例凝溶异常患者的182份样本。对于DIC的诊断，PIC的敏感性显著高于DIC评分（78.46%对43.08%；卡方检验p<0.01），尽管PIC的特异性显著低于DIC评分（32.48%对69.23%；卡方检验p<0.01）。对于预后预测，评估了患者临床病程中PIC和DIC评分的峰值。非存活者（n = 33）的PIC峰值和DIC评分水平显著高于存活者（n = 27）（PIC峰值：6.1 + 9.0微克/毫升对2.2 + 3.3，p<0.05；DIC评分峰值：4.6 + 2.4分对3.3 + 2.2，p<0.05）。PIC峰值超过4.0微克/毫升的患者死亡率超过90%。这些结果表明，PIC是一个有用的诊断和预后参数。
