Hirsch Tobias, Jacobsen Frank, Steinau Hans-Ulrich, Steinstraesser Lars
Department for Plastic Surgery, Burn Center, BG University Hospital Bergmannsheil, Ruhr University Bochum, Germany.
Protein Pept Lett. 2008;15(3):238-43. doi: 10.2174/092986608783744252.
Increasing antibiotic resistance has led to an urgent need for new therapeutic approaches. Host defense peptides are known to be antimicrobial and have revealed broad immunomodulatory functions for both innate and adaptive immunity. This review will focus on the role of host defense peptides in infection and immune response and discuss its potential and limitations as a future therapeutical agent.
抗生素耐药性的不断增加导致了对新治疗方法的迫切需求。宿主防御肽已知具有抗菌作用，并已显示出对先天免疫和适应性免疫的广泛免疫调节功能。本综述将重点关注宿主防御肽在感染和免疫反应中的作用，并讨论其作为未来治疗剂的潜力和局限性。
