宿主防御肽作为先天免疫反应的效应分子：耐药性的大棒？
Host defense peptides as effector molecules of the innate immune response: a sledgehammer for drug resistance?
机构信息
Department of Plastic and Reconstructive Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Nordrhein-Westfalen, Germany.
Department of Oral and Maxillofacial Surgery, Technische Universität München, Ismaninger Str. 22, München, Germany.
出版信息
Int J Mol Sci. 2009 Sep 9;10(9):3951-3970. doi: 10.3390/ijms10093951.
Abstract
Host defense peptides can modulate the innate immune response and boost infection-resolving immunity, while dampening potentially harmful pro-inflammatory (septic) responses. Both antimicrobial and/or immunomodulatory activities are an integral part of the process of innate immunity, which itself has many of the hallmarks of successful anti-infective therapies, namely rapid action and broad-spectrum antimicrobial activities. This gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections. This review details the role and activities of these peptides, and examines their applicability as development candidates for use against bacterial infections.
摘要
宿主防御肽可以调节先天免疫反应，增强抗感染的免疫能力，同时抑制潜在的有害促炎（脓毒性）反应。抗菌和/或免疫调节活性是先天免疫过程的一个组成部分，而先天免疫本身具有许多成功的抗感染疗法的特征，即快速作用和广谱抗菌活性。这使得这些肽有可能成为一种针对细菌感染的全新治疗方法。本文详细介绍了这些肽的作用和活性，并研究了它们作为开发针对细菌感染的候选药物的适用性。
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