Arana Estanislao, Martí-Bonmatí Luis, Tobarra Eva, Sierra Consuelo
Department of Radiology, Hospital Quirón, E-4610 Valencia, Spain.
Eur J Radiol. 2009 Jun;70(3):507-11. doi: 10.1016/j.ejrad.2008.01.048. Epub 2008 Mar 11.
To analyze the influence of contrast dose adjusted by weight vs. fixed contrast dose in the attenuation and cost of abdominal computed tomography (CT).
A randomised, consecutive, parallel group study was conducted in 151 patients (74 men and 77 women, age range 22-67 years), studied with the same CT helical protocol. A dose at 1.75 ml/kg was administered in 101 patients while 50 patients had a fixed dose of 120 ml of same non-ionic contrast material (320 mg/ml). Mean enhancements were measured at right hepatic lobe, superior abdominal aorta and inferior cava vein. Statistical analysis was weight-stratified (<60, 61-70, 71-80 and >81 kg).
Aortic attenuation was significantly superior (p<0.05) in the dose adjusted by weight group than in the fixed dose group. Patients who weighed >61 kg in dose-adjusted group, presented higher hepatic attenuation, being statistically significant in those >81 kg (p<0.01). In dose-adjusted group, there was a savings of euro 4.1 per patient in patients weighing <80 kg. In patients weighing >80 kg, there was an over cost of euro 10.7 per patient.
An injection volume of 1.75 ml/kg offers an optimal diagnostic quality with a global savings of euro 1.34 per patient.
分析根据体重调整对比剂剂量与固定对比剂剂量对腹部计算机断层扫描（CT）衰减及成本的影响。
对151例患者（74例男性和77例女性，年龄范围22 - 67岁）进行了一项随机、连续、平行组研究，所有患者均采用相同的CT螺旋扫描方案。101例患者给予1.75 ml/kg的剂量，而50例患者给予固定剂量120 ml相同的非离子型对比剂（320 mg/ml）。在肝右叶、腹主动脉上段和下腔静脉测量平均强化值。统计分析按体重分层（<60、61 - 70、71 - 80和>81 kg）。
按体重调整剂量组的主动脉衰减显著优于固定剂量组（p<0.05）。在按剂量调整组中，体重>61 kg的患者肝衰减较高，体重>81 kg的患者差异有统计学意义（p<0.01）。在按剂量调整组中，体重<80 kg的患者每人节省4.1欧元。体重>80 kg的患者每人超支10.7欧元。
1.75 ml/kg的注射量可提供最佳诊断质量，每位患者总体节省1.34欧元。
