使用来曲唑诱导排卵会致畸吗？
Is the use of letrozole to induce ovulation teratogenic?
作者信息
Gill Simerpal Kaur, Moretti Myla, Koren Gideon
出版信息
Can Fam Physician. 2008 Mar;54(3):353-4.
Abstract
QUESTION
A patient of mine has been prescribed letrozole to induce ovulation; however, a recent release from the Food and Drug Administration contraindicates the use of letrozole in premenopausal women owing to teratogenicity. Does the use of letrozole increase the risk of a child being born with a birth defect?
ANSWER
The use of letrozole to induce ovulation has not been associated with an increased risk of a child being born with a birth defect; in contrast, the use of clomiphene citrate in pregnancy is associated with intrauterine growth restriction.
摘要
问题
我的一位患者被开了来曲唑以诱导排卵；然而，美国食品药品监督管理局最近发布的信息因致畸性而禁止绝经前女性使用来曲唑。使用来曲唑会增加孩子出生时出现出生缺陷的风险吗？
答案
使用来曲唑诱导排卵与孩子出生时出现出生缺陷的风险增加并无关联；相反，孕期使用枸橼酸氯米芬与宫内生长受限有关。
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