新型5-羟色胺3受体拮抗剂GR38032F对豚鼠胃排空的影响。
The effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pig.
作者信息
Costall B, Gunning S J, Naylor R J, Tyers M B
出版信息
Br J Pharmacol. 1987 Jun;91(2):263-4. doi: 10.1111/j.1476-5381.1987.tb10280.x.
Abstract
The effects of GR38032F a novel, selective and potent 5-hydroxytryptamine (5-HT3)-receptor antagonist on gastric emptying in the guinea-pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose-dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.
摘要
研究了新型、选择性且强效的5-羟色胺（5-HT3）受体拮抗剂GR38032F对豚鼠胃排空的影响，并与胃复安和氟哌啶醇进行了比较。GR38032F和胃复安均以剂量依赖方式增加胃排空。相比之下，氟哌啶醇无效。在研究的2小时期间，GR38032F增强胃排空的效力比胃复安高约200倍。
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