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本文引用的文献

1
Interaction of levodopa and metoclopramide on gastric emptying.
Clin Pharmacol Ther. 1980 Mar;27(3):414-20. doi: 10.1038/clpt.1980.55.
2
Metoclopramide. An updated review of its pharmacological properties and clinical use.甲氧氯普胺。对其药理特性及临床应用的最新综述。
Drugs. 1983 May;25(5):451-94. doi: 10.2165/00003495-198325050-00002.
3
5-Hydroxytryptamine receptor antagonism by metoclopramide and ICS 205-930 in the guinea-pig leads to enhancement of contractions of stomach muscle strips induced by electrical field stimulation and facilitation of gastric emptying in-vivo.甲氧氯普胺和ICS 205 - 930对豚鼠5 - 羟色胺受体的拮抗作用导致电场刺激引起的胃肌条收缩增强以及体内胃排空加快。
J Pharm Pharmacol. 1985 Sep;37(9):664-7. doi: 10.1111/j.2042-7158.1985.tb05109.x.

新型5-羟色胺3受体拮抗剂GR38032F对豚鼠胃排空的影响。

The effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pig.

作者信息

Costall B, Gunning S J, Naylor R J, Tyers M B

出版信息

Br J Pharmacol. 1987 Jun;91(2):263-4. doi: 10.1111/j.1476-5381.1987.tb10280.x.

DOI:10.1111/j.1476-5381.1987.tb10280.x
PMID:2955843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853517/
Abstract

The effects of GR38032F a novel, selective and potent 5-hydroxytryptamine (5-HT3)-receptor antagonist on gastric emptying in the guinea-pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose-dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.

摘要

研究了新型、选择性且强效的5-羟色胺（5-HT3）受体拮抗剂GR38032F对豚鼠胃排空的影响，并与胃复安和氟哌啶醇进行了比较。GR38032F和胃复安均以剂量依赖方式增加胃排空。相比之下，氟哌啶醇无效。在研究的2小时期间，GR38032F增强胃排空的效力比胃复安高约200倍。