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三芳基吡啶：用于识别G-四链体的多功能小分子骨架

Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition.

作者信息

Waller Zoë A E, Shirude Pravin S, Rodriguez Raphaël, Balasubramanian Shankar

机构信息

The University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK.

出版信息

Chem Commun (Camb). 2008 Mar 28(12):1467-9. doi: 10.1039/b718854d. Epub 2008 Jan 29.

DOI:10.1039/b718854d
PMID:18338058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2527513/
Abstract

The triarylpyridines are potent G-quadruplex ligands that are highly discriminating against duplex DNA and show promising selectivity between intramolecular quadruplexes.

摘要

三芳基吡啶是有效的G-四链体配体，对双链DNA具有高度选择性，并且在分子内四链体之间表现出有前景的选择性。

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本文引用的文献

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J Am Chem Soc. 2007 Oct 31;129(43):12926-7. doi: 10.1021/ja075881p. Epub 2007 Oct 5.
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Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.大环和螺旋状低聚酰胺作为一类新型的G-四链体配体。
J Am Chem Soc. 2007 Oct 3;129(39):11890-1. doi: 10.1021/ja073775h. Epub 2007 Sep 11.
3
Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.原癌基因c-kit启动子DNA双链中G-四链体形成的单分子构象分析
J Am Chem Soc. 2007 Jun 20;129(24):7484-5. doi: 10.1021/ja070497d. Epub 2007 May 25.
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Tetraplex DNA and its interacting proteins.四链体DNA及其相互作用蛋白。
Front Biosci. 2007 May 1;12:4336-51. doi: 10.2741/2391.
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Fluorescence-based melting assays for studying quadruplex ligands.用于研究四链体配体的基于荧光的熔解分析。
Methods. 2007 Jun;42(2):183-95. doi: 10.1016/j.ymeth.2006.10.004.
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J Med Chem. 2007 Apr 5;50(7):1465-74. doi: 10.1021/jm0610088. Epub 2007 Mar 9.
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