Tolstykh O I, Khmelevskiĭ Iu V
Vopr Pitan. 1991 May-Jun(3):38-42.
Cardiac hypertrophy in rats was induced by the narrowing of the abdominal aorta 3.14 and 30 days before the experiment. It has been shown that activation of NADP.H production under these conditions leads to elevation of NADP.H-dependent lipid peroxidation (LPO) level and to decrease of glutathione reductase (GR) activity, that means that changes take place in the antioxidant state of the cardiac tissue. Use of alpha-tocopherol and thiamine normalizes LPO level and induces elevation of GR activity. These data when compared with those obtained in investigation of the cardiac pumping function during its intensive activity could be estimated as favourable prerequisites for prevention of cardiac insufficiency.
在实验前3.14天和30天通过腹主动脉缩窄诱导大鼠心脏肥大。研究表明，在这些条件下NADP.H生成的激活会导致NADP.H依赖性脂质过氧化（LPO）水平升高和谷胱甘肽还原酶（GR）活性降低，这意味着心脏组织的抗氧化状态发生了变化。使用α-生育酚和硫胺素可使LPO水平正常化并诱导GR活性升高。与在心脏强烈活动期间对心脏泵血功能的研究中获得的数据相比，这些数据可被视为预防心脏功能不全的有利前提条件。
