Sardar S, Chakraborty A, Chatterjee M
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Int J Vitam Nutr Res. 1996;66(1):39-45.
The vitamin D-endocrine system has mostly been studied for its role in calcium and phosphorus metabolism and its possible role as an antioxidant has been neglected. This study attempts to elucidate the antioxidative properties of the prohormone with respect to vitamin E, a membrane antioxidant. Results herein show that D3 treatment brought about similar reduction in the extent of lipid peroxidation and induction in superoxide dismutase (SOD) activity, as with vitamin E supplementation. While selenium dependent glutathione peroxidase (Sedep. GPx) activity reflected no change with vitamin D3 treatment, total GPx activity was more significantly influenced by vitamin D3 than by vitamin E. The glutathione (GSH) content in the experimental rats also reflected similar changes. Vitamin E supplementation caused 8.57% increase in glutathione reductase (GR) activity, while vitamin D3 decreased the concerned enzymes activity by 11.11%. Vitamin D3 treatment also caused 25% increase in glucose 6-phosphate dehydrogenase (G6PD) activity. These data thus suggest that vitamin D3 may function as an antioxidant in the liver in vivo and illustrate an effectiveness higher than that observed with vitamin E supplementation.
维生素D内分泌系统主要因其在钙和磷代谢中的作用而被研究，其作为抗氧化剂的潜在作用却被忽视了。本研究试图阐明这种激素原相对于膜抗氧化剂维生素E的抗氧化特性。本文结果表明，维生素D3处理导致脂质过氧化程度的降低以及超氧化物歧化酶（SOD）活性的诱导，与补充维生素E的效果相似。虽然依赖硒的谷胱甘肽过氧化物酶（Sedep.GPx）活性在维生素D3处理后没有变化，但总GPx活性受维生素D3的影响比受维生素E的影响更显著。实验大鼠体内的谷胱甘肽（GSH）含量也呈现出相似的变化。补充维生素E使谷胱甘肽还原酶（GR）活性增加了8.57%，而维生素D3使相关酶的活性降低了11.11%。维生素D3处理还使葡萄糖6-磷酸脱氢酶（G6PD）活性增加了25%。因此，这些数据表明维生素D3在体内肝脏中可能作为一种抗氧化剂发挥作用，并且其效果高于补充维生素E所观察到的效果。
