Hobday R A, Thomas S, O'Donovan A, Murphy M, Pinching A J
Infection and Immunity Speciality Group, St Bartholomew's Hospital, West Smithfield, London, UK.
J Hum Nutr Diet. 2008 Apr;21(2):141-9. doi: 10.1111/j.1365-277X.2008.00857.x.
Anecdotal reports and books have been published linking an over growth of Candida Albicans with chronic fatigue syndrome (CFS), suggesting dietary change as a treatment option. Little scientific data has been published to validate this controversial theory. This study aims to determine the efficacy of dietary intervention on level of fatigue and quality of life (QoL) in individuals with CFS.
A 24-week randomized intervention study was conducted with 52 individuals diagnosed with CFS. Patients were randomized to either a low sugar low yeast (LSLY) or healthy eating (HE) dietary interventions. Primary outcome measures were fatigue as measured by the Chalder Fatigue Score and QoL measured by Medical Outcomes Survey Short Form-36.
A high drop out rate occurred with 13 participants not completing the final evaluation (7HE/6LSLY). Intention to treat analysis showed no statistically significant differences on primary outcome measurements.
In this randomized control trial, a LSLY diet appeared to be no more efficacious on levels of fatigue or QoL compared to HE. Given the difficulty with dietary compliance experienced by participants, especially in the LSLY group, it would appear HE guidance is a more pragmatic approach than advocating a complicated dietary regime.
已有轶事报道和书籍发表，将白色念珠菌过度生长与慢性疲劳综合征（CFS）联系起来，并提出饮食改变作为一种治疗选择。但几乎没有科学数据来证实这一有争议的理论。本研究旨在确定饮食干预对慢性疲劳综合征患者疲劳水平和生活质量（QoL）的疗效。
对52名被诊断为慢性疲劳综合征的个体进行了一项为期24周的随机干预研究。患者被随机分配到低糖低酵母（LSLY）或健康饮食（HE）饮食干预组。主要结局指标是通过查尔德疲劳评分测量的疲劳程度以及通过医学结局调查简表36测量的生活质量。
出现了较高的退出率，13名参与者未完成最终评估（7名HE组/6名LSLY组）。意向性分析显示，在主要结局测量方面无统计学显著差异。
在这项随机对照试验中，与健康饮食相比，低糖低酵母饮食在疲劳水平或生活质量方面似乎并无更多疗效。鉴于参与者在饮食依从性方面存在困难，尤其是在低糖低酵母组，健康饮食指导似乎比倡导复杂的饮食方案更务实。
