Değertekin Halil, Yalçin Kendal, Yakut Mustafa, Yurdaydin Cihan
Department of Gastroenterology, Ufuk University School of Medicine, Ankara, Turkey.
Liver Int. 2008 Apr;28(4):494-8. doi: 10.1111/j.1478-3231.2008.01673.x.
Recent reports suggest a decline of delta hepatitis (DH) in the West as well as in the Far East.
To study the DH seroepidemiology in Turkey.
Statistical power analysis was utilized based on data available in a recent article using prevalence figure estimates. Binominal distribution was applied in order to assess the number of samples required to estimate the prevalence with a given precision.
Out of 62 studies in the original study, 32 were eliminated because of insufficient power. A total of 6734 patients (5231 with chronic hepatitis and 1503 with cirrhosis) were analysed. Anti-HDV seropositivity among patients with chronic hepatitis B (CHB) and hepatitis B-induced cirrhosis was lowest in the west of the country and highest in the southeast (5 vs. 27%, P<0.0001 and 20 vs. 46%, P<0.0001) respectively. Compared with data obtained before 1995, after 1995, DH prevalence in patients with CHB and cirrhosis decreased from 29 to 12% (P<0.0001) and from 38 to 27% (P=0.03) in central and southeast Turkey and from 38 to 20% (P<0.0001) and from 66 to 46% (P<0.002) in west and southeast Turkey respectively.
Despite the decrease of its prevalence in Turkey, DH remains a significant health problem in parts of the country with low socio-economic level.
近期报告显示，西方以及远东地区的丁型肝炎（DH）发病率有所下降。
研究土耳其的丁型肝炎血清流行病学。
根据近期一篇文章中可用的数据及患病率估计值进行统计功效分析。应用二项分布来评估以给定精度估计患病率所需的样本数量。
在原研究的62项研究中，有32项因功效不足而被排除。共分析了6734例患者（5231例慢性肝炎患者和1503例肝硬化患者）。慢性乙型肝炎（CHB）患者和乙型肝炎所致肝硬化患者中的抗HDV血清阳性率在该国西部最低，在东南部最高（分别为5%对27%，P<0.0001；20%对46%，P<0.0001）。与1995年前获得的数据相比，1995年后，土耳其中部和东南部CHB患者和肝硬化患者的丁型肝炎患病率分别从29%降至12%（P<0.0001）和从38%降至27%（P=0.03），西部和东南部则分别从38%降至20%（P<0.0001）和从66%降至46%（P<0.002）。
尽管土耳其丁型肝炎的患病率有所下降，但在该国社会经济水平较低的地区，丁型肝炎仍是一个严重的健康问题。
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