Gonçalves R, Penderis J, Chang Y P, Zoia A, Mosley J, Anderson T J
Division of Companion Animal Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow G61 1QH, UK.
J Small Anim Pract. 2008 Apr;49(4):178-84. doi: 10.1111/j.1748-5827.2007.00530.x.
To characterise the clinical presentation and neurological abnormalities in dogs affected by aortic thromboembolism.
The medical records of 13 dogs diagnosed with aortic thromboembolism as the cause of the clinical signs, and where a complete neurological examination was performed, were reviewed retrospectively.
The onset was acute in only four dogs, chronic in five dogs (with all of these presenting as exercise intolerance) or chronic with acute deterioration in four dogs. Dogs with an acute onset of clinical signs were more severely affected exhibiting neurological deficits, while dogs with a chronic onset of disease predominantly presented with the exercise intolerance and minimal deficits. The locomotor deficits included exercise intolerance with pelvic limb weakness (five of 13), pelvic limb ataxia (one of 13), monoparesis (two of 13), paraparesis (two of 13), non-ambulatory paraparesis (two of 13) and paraplegia (one of 13). There was an apparent male predisposition and the cavalier King charles spaniel was overrepresented.
The rate of onset of clinical signs appears to segregate dogs affected by aortic thromboembolism into two groups, with different clinical characteristics and outcomes. Dogs with an acute onset of the clinical signs tend to be more severely affected, while dogs with a chronic onset predominantly present with exercise intolerance. It is therefore important to consider aortic thromboembolism as a differential diagnosis in dogs with an acute onset of pelvic limb neurological deficits and in dogs with longer standing exercise intolerance.
描述受主动脉血栓栓塞影响的犬的临床表现和神经异常。
回顾性分析13只被诊断为主动脉血栓栓塞导致临床症状且进行了完整神经学检查的犬的病历。
仅4只犬发病急，5只犬发病慢（均表现为运动不耐受），4只犬发病慢但有急性恶化。临床症状急性发作的犬受影响更严重，表现出神经功能缺损，而发病慢的犬主要表现为运动不耐受且缺损轻微。运动功能缺损包括运动不耐受伴后肢无力（13只中的5只）、后肢共济失调（13只中的1只）、单瘫（13只中的2只）、截瘫（13只中的2只）、非行走性截瘫（13只中的2只）和截瘫（13只中的1只）。明显雄性易患，骑士查理王小猎犬占比过高。
临床症状的发作率似乎将受主动脉血栓栓塞影响的犬分为两组，具有不同的临床特征和预后。临床症状急性发作的犬往往受影响更严重，而发病慢的犬主要表现为运动不耐受。因此，在急性发作后肢神经功能缺损的犬和长期运动不耐受的犬中，将主动脉血栓栓塞作为鉴别诊断很重要。
