意大利南部人群中人乳头瘤病毒感染的患病率及基因型鉴定
Prevalence and genotypes identification of human papillomavirus infection in a population of South Italy.
作者信息
Del Prete Raffaele, Di Taranto Anna Maria, Lipsi Maria Rosaria, Nirchio Vincenzo, Antonetti Raffaele, Miragliotta Giuseppe
机构信息
Section of Microbiology, Department of Clinical Medicine, Immunology, Infectious Diseases, University of Bari, Piazza Giulio Cesare, 70124 Bari, Italy.
出版信息
J Clin Virol. 2008 Jun;42(2):211-4. doi: 10.1016/j.jcv.2008.01.011. Epub 2008 Mar 14.
BACKGROUND
A limited number of human papillomavirus (HPV) types account for the majority of invasive cervical cancer cases.
OBJECTIVES
To assess, in a southern Italian region, where HPV infection had not yet been investigated, the prevalence of type-specific HPV infection.
STUDY DESIGN
Multiplex PCR was used to test cervical specimens from 871 asymptomatic women.
RESULTS
The HPV infection rate was 23.1%, with the highest prevalence being observed in women aged 20-30 years (32.6%). Type 16 was the most frequent HPV type detected either in mono-infected (39.8%) or in multi-infected (46.3%) women.
CONCLUSIONS
The HPV infection rate was higher than reported from other Italian areas. Our results further emphasise the importance of vaccinations to immunize females before they acquire HPV infection.
背景
少数人乳头瘤病毒（HPV）类型导致了大多数浸润性宫颈癌病例。
目的
在意大利南部一个尚未对HPV感染进行调查的地区，评估特定类型HPV感染的患病率。
研究设计
采用多重聚合酶链反应（Multiplex PCR）检测871名无症状女性的宫颈标本。
结果
HPV感染率为23.1%，在20至30岁女性中患病率最高（32.6%）。16型是在单一感染（39.8%）或多重感染（46.3%）女性中检测到的最常见HPV类型。
结论
HPV感染率高于意大利其他地区报告的水平。我们的结果进一步强调了在女性感染HPV之前进行疫苗接种以实现免疫的重要性。
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