Fleischer Roni, Weston Gareth C, Vollenhoven Beverley J, Rogers Peter A W
Department of Obstetrics & Gynaecology, Monash University, Level 5 Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia.
Best Pract Res Clin Obstet Gynaecol. 2008 Aug;22(4):603-14. doi: 10.1016/j.bpobgyn.2008.01.005. Epub 2008 Mar 12.
Uterine fibroids are the most common tumours presenting in women. The pathophysiology of fibroids is poorly understood, but disordered angiogenesis and altered smooth muscle cell proliferation are believed to play a role. In this review, current knowledge of both of these processes will be summarized. Differences between 'normal' adjacent myometrium and fibroid tumours within the same uterus are outlined. Exploiting these differences represents one of the best opportunities for the development of medical treatments that target fibroid tissue selectively.
子宫肌瘤是女性中最常见的肿瘤。子宫肌瘤的病理生理学尚不清楚，但据信血管生成紊乱和平滑肌细胞增殖改变起了作用。在这篇综述中，将总结关于这两个过程的现有知识。概述了同一子宫内“正常”相邻肌层与肌瘤肿瘤之间的差异。利用这些差异是开发选择性靶向肌瘤组织的医学治疗方法的最佳机会之一。
