Sokero Petteri, Melartin Tarja, Rytsälä Heikki, Leskelä Ulla, Lestelä-Mielonen Paula, Isometsä Erkki
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
J Nerv Ment Dis. 2008 Mar;196(3):223-9. doi: 10.1097/NMD.0b013e31816634f5.
We examined differences in treatments received, and attitudes and adherence to them between suicidal and nonsuicidal patients with major depressive disorder (MDD). Psychiatric MDD patients with no suicidal behavior (N = 92), suicidal ideation (N = 92), or attempts (N = 34) were compared during 6 months of follow-up in the Vantaa Depression Study (VDS). Patients with suicidal behavior received antidepressants or adequate antidepressant treatment significantly more often, had more frequent appointments with psychiatrists, more psychotherapeutic support, and more favorable attitudes toward antidepressant treatment than nonsuicidal patients. However, after adjusting for the confounding severity of depression, the significance of these differences was lost. Adherence to treatment was similar in the patient groups. Overall, among psychiatric patients with MDD, those known to be suicidal have higher suicide risk and should receive more intensive treatment. However, suicidal behavior per se does not seem to markedly influence treatments provided nor should it be associated with negative attitudes or poor adherence to treatments.
我们研究了重度抑郁症(MDD)自杀患者与非自杀患者在接受治疗、对治疗的态度及依从性方面的差异。在万塔抑郁症研究(VDS)中,对6个月随访期间无自杀行为(N = 92)、有自杀意念(N = 92)或有自杀未遂经历(N = 34)的精神科MDD患者进行了比较。与非自杀患者相比,有自杀行为的患者更频繁地接受抗抑郁药或充分的抗抑郁治疗,更频繁地预约精神科医生,获得更多心理治疗支持,且对抗抑郁治疗的态度更积极。然而,在对抑郁症的严重程度这一混杂因素进行校正后,这些差异不再具有统计学意义。各患者组的治疗依从性相似。总体而言,在患有MDD的精神科患者中,已知有自杀倾向的患者自杀风险更高,应接受更强化的治疗。然而,自杀行为本身似乎并未显著影响所提供的治疗,也不应与消极态度或治疗依从性差相关联。