Wishart J M
Department of Dermatology, Auckland Hospital, New Zealand.
Australas J Dermatol. 1991;32(1):51-4. doi: 10.1111/j.1440-0960.1991.tb00683.x.
Levonorgestrel, as used in oral contraceptives, has antiovulatory activity at doses far lower than those producing androgenic effects. Triphasil, containing levonorgestrel was compared with Diane, containing cyproterone acetate in a trial of acne treatment. Twenty closely matched patients were alternatively allocated to 6 months of Triphasil or Diane treatment. Both groups had a 72% reduction in acne counts. Assays of total testosterone, androgen index, free testosterone, dehydroepiandrosterone sulphate and androstenedione showed significant reduction on treatment and sex hormone binding globulin was raised. All hormonal changes were more marked in the Diane group. Side effects caused only one withdrawal from the trial.
左炔诺孕酮用于口服避孕药时，其产生抗排卵作用的剂量远低于产生雄激素作用的剂量。在一项痤疮治疗试验中，对含左炔诺孕酮的三相片（Triphasil）与含醋酸环丙孕酮的达英（Diane）进行了比较。20名匹配良好的患者被交替分配接受6个月的三相片或达英治疗。两组的痤疮数量均减少了72%。总睾酮、雄激素指数、游离睾酮、硫酸脱氢表雄酮和雄烯二酮的检测显示治疗后显著降低，且性激素结合球蛋白升高。所有激素变化在达英组更为明显。副作用仅导致1例患者退出试验。
