Flower D R, North A C, Attwood T K
Department of Biochemistry and Molecular Biology, University of Leeds, UK.
Biochem Biophys Res Commun. 1991 Oct 15;180(1):69-74. doi: 10.1016/s0006-291x(05)81256-2.
Rigorous new methods of protein sequence analysis have been applied to the lipocalins, a diverse family of ligand binding proteins. Using three conserved sequence motifs to search for similar patterns in a large sequence database, the size and composition of this protein family have been defined in an automatic and objective way. It has allowed the identification of an existing sequence, mouse 24p3 protein, as a lipocalin and the possible rejection of other putative members from this protein family. On the basis of this newly discovered homology, a possible function for mouse 24p3 protein is proposed.
蛋白质序列分析的严格新方法已应用于脂质运载蛋白，这是一类多样的配体结合蛋白家族。利用三个保守序列基序在大型序列数据库中搜索相似模式，以自动且客观的方式定义了这个蛋白质家族的大小和组成。这使得能够将现有的序列——小鼠24p3蛋白鉴定为脂质运载蛋白，并可能排除该蛋白质家族中其他假定的成员。基于这一新发现的同源性，提出了小鼠24p3蛋白的一种可能功能。
