Jobson V W
Forsyth Memorial Hospital, Winston-Salem, North Carolina.
Oncology (Williston Park). 1991 Aug;5(8):69-72, 77; discussion 79-81, 84.
Over the past 20 years, the incidence of invasive genital neoplasia has decreased, while the incidence of preinvasive, or intraepithelial, neoplasia has increased. These trends are the result of increased cancer screening women and the widespread application of improved diagnostic techniques by physicians. The rapid increase in genital human papillomavirus infections over the past 10 years may also be a factor influencing the increased incidence of intraepithelial neoplasia. The average age at diagnosis of genital intraepithelial neoplasia has decreased, thereby heightening the need for more conservative treatment options. The application of cryosurgical techniques during the 1970s and the introduction of lasers in the 1980s have fulfilled this need for less mutilative, organ-preserving treatment.
在过去20年里，浸润性生殖器肿瘤的发病率有所下降，而癌前或上皮内肿瘤的发病率则有所上升。这些趋势是女性癌症筛查增加以及医生广泛应用改进的诊断技术的结果。过去10年里生殖器人乳头瘤病毒感染的迅速增加也可能是影响上皮内肿瘤发病率上升的一个因素。生殖器上皮内肿瘤的平均诊断年龄有所下降，因此更加需要更保守的治疗选择。20世纪70年代冷冻手术技术的应用以及80年代激光的引入满足了这种对破坏性较小、保留器官治疗的需求。
