Qiu Yan, Zhu Feng, Liao Yu-hua, Li Zheng-zai, Wang Min
Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science Technology, Wuhan 430022, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2007 Dec;35(12):1141-4.
To observe the association between positive autoantibodies against AT(1)-receptor and cardiac remodeling in primary hypertensive patients.
Echocardiography was performed and serum autoantibodies against AT(1)-receptor were detected by enzyme linked immunosorbent assay (ELISA) in 592 patients with primary hypertension. The differences on blood pressure level, course of hypertension, vasoactive substance and echocardiography parameters between the positive group and negative group were compared. Factors related to left ventricular enlargement were analyzed by multiple logistic regressions.
The positive percentage of autoantibodies against AT(1)-receptor was 38.0% (225/592). End-diastolic right atrial and left ventricular diameters in positive group were significantly larger than that in negative group (P = 0.049 and P = 0.044, respectively). Regression analysis demonstrated that positive autoantibodies against AT(1)-receptor, male gender, diastolic blood pressure and course of hypertension were related to left ventricular enlargement (all P < 0.05).
The autoantibodies against AT(1)-receptor is associated with left ventricular and right atrial enlargement in hypertensive patients.
观察原发性高血压患者抗血管紧张素Ⅱ1型受体（AT(1)-受体）自身抗体阳性与心脏重塑之间的关联。
对592例原发性高血压患者进行超声心动图检查，并采用酶联免疫吸附测定（ELISA）法检测血清抗AT(1)-受体自身抗体。比较阳性组和阴性组在血压水平、高血压病程、血管活性物质及超声心动图参数方面的差异。通过多元逻辑回归分析与左心室扩大相关的因素。
抗AT(1)-受体自身抗体阳性率为38.0%（225/592）。阳性组舒张末期右心房和左心室直径显著大于阴性组（分别为P = 0.049和P = 0.044）。回归分析表明，抗AT(1)-受体自身抗体阳性、男性性别、舒张压和高血压病程与左心室扩大有关（均P < 0.05）。
高血压患者抗AT(1)-受体自身抗体与左心室及右心房扩大有关。
