Ren Li, Yi Jie, Yang Jing, Li Peng, Cheng Xueyan, Mao Peixian
Department of Neurology, Beijing An Ding Hospital, Beijing, P. R. China.
Medicine (Baltimore). 2018 Sep;97(37):e12172. doi: 10.1097/MD.0000000000012172.
Previous studies have indicated that nonsteroidal anti-inflammatory drugs (NSAIDs) use is associated with Parkinson disease risk, but presented controversial results.Medline, Embase, Web of Science, and the Cochrane Database were searched update to November 2017. Key data were extracted from eligible studies. A dose-response meta-analysis was conducted for synthesizing data from eligible studies.Fifteen eligible studies were included in this meta-analysis. NSAIDs use was not associated with Parkinson disease risk [relevant risk (RR): 0.06; 95% confidence interval (95% CI), 0.91-1.02]. Subgroup analysis showed that aspirin use (RR: 1.14; 95% CI, 0.98-1.30) or ibuprofen use (RR: 1.01; 95% CI, 0.88-1.17) was not associated with Parkinson disease risk; however, the use of non-aspirin NSAIDs was significantly associated with Parkinson disease risk (RR:0.91; 95% CI, 0.84-0.99). Furthermore, NSAIDs use was not associated with the risk of Parkinson disease in female (RR: 0.99; 95% CI, 0.83-1.17) and male (RR: 1.01; 95% CI, 0.88-1.16). In addition, a dose-response showed per 1 number of prescription incremental increase in NSAIDs use was not associated with the risk of Parkinson disease (RR: 0.96; 95% CI, 0.91-1.02), per 1 year of duration of NSAIDs use incremental increase was not associated with the risk of Parkinson disease (RR: 0.98; 95% CI, 0.92-1.03), and per 1 dosage of NSAIDs use incremental increase was not associated with the risk of Parkinson disease (RR: 0.98; 95% CI, 0.95-1.02).NSAIDs use was not associated with the risk of Parkinson disease. The potency and the cumulative NSAIDs use did not play critical roles.
先前的研究表明，使用非甾体抗炎药（NSAIDs）与帕金森病风险相关，但结果存在争议。检索了截至2017年11月的Medline、Embase、Web of Science和Cochrane数据库。从符合条件的研究中提取关键数据。进行剂量反应荟萃分析以综合符合条件的研究数据。本荟萃分析纳入了15项符合条件的研究。使用NSAIDs与帕金森病风险无关[相对风险（RR）：0.06；95%置信区间（95%CI），0.91 - 1.02]。亚组分析显示，使用阿司匹林（RR：1.14；95%CI，0.98 - 1.30）或布洛芬（RR：1.01；95%CI，0.88 - 1.17）与帕金森病风险无关；然而，使用非阿司匹林类NSAIDs与帕金森病风险显著相关（RR：0.91；95%CI，0.84 - 0.99）。此外，使用NSAIDs与女性（RR：0.99；95%CI，0.83 - 1.17）和男性（RR：1.01；95%CI，0.88 - 1.16）的帕金森病风险均无关。另外，剂量反应显示，NSAIDs使用量每增加1份处方与帕金森病风险无关（RR：0.96；95%CI，0.91 - 1.02），NSAIDs使用时长每增加1年与帕金森病风险无关（RR：0.98；95%CI，0.92 - 1.03），NSAIDs使用剂量每增加1单位与帕金森病风险无关（RR：0.98；95%CI，0.95 - 1.02）。使用NSAIDs与帕金森病风险无关。NSAIDs的效力和累积使用量并未起到关键作用。
