Alrouji Mohammed, Al-Kuraishy Hayder M, Al-Gareeb Ali I, Saad Hebatallah M, Batiha Gaber El-Saber
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Shaqra University, Shaqra, 11961, Saudi Arabia.
Professor in Department of Clinical Pharmacology and Therapeutic Medicine, College of Medicine, ALmustansiriyiah University, M.B.Ch.B, FRCP, Box 14132, Baghdad, Iraq.
Inflammopharmacology. 2023 Apr;31(2):673-688. doi: 10.1007/s10787-023-01192-2. Epub 2023 Mar 24.
Parkinson's disease (PD) is an advanced neurodegenerative disease (NDD) caused by the degeneration of dopaminergic neurons (DNs) in the substantia nigra (SN). As PD is an age-related disorder, the majority of PD patients are associated with musculoskeletal disorders with prolonged use of analgesic and anti-inflammatory agents, such as non-steroidal anti-inflammatory drugs (NSAIDs). Therefore, NSAIDs can affect PD neuropathology in different ways. Thus, the objective of the present narrative review was to clarify the potential role of NSAIDs in PD according to the assorted view of preponderance. Inhibition of neuroinflammation and modulation of immune response by NSAIDs could be an effective way in preventing the development of NDD. NSAIDs affect PD neuropathology in different manners could be beneficial or detrimental effects. Inhibition of cyclooxygenase 2 (COX2) by NSAIDs may prevent the development of PD. NSAIDs afforded a neuroprotective role against the development and progression of PD neuropathology through the modulation of neuroinflammation. Though, NSAIDs may lead to neutral or harmful effects by inhibiting neuroprotective prostacyclin (PGI2) and accentuation of pro-inflammatory leukotrienes (LTs). In conclusion, there is still a potential conflict regarding the effect of NSAIDs on PD neuropathology.
帕金森病（PD）是一种由黑质（SN）中多巴胺能神经元（DNs）变性引起的晚期神经退行性疾病（NDD）。由于PD是一种与年龄相关的疾病，大多数PD患者伴有肌肉骨骼疾病，长期使用镇痛和抗炎药物，如非甾体抗炎药（NSAIDs）。因此，NSAIDs可以通过不同方式影响PD神经病理学。因此，本叙述性综述的目的是根据各种优势观点阐明NSAIDs在PD中的潜在作用。NSAIDs对神经炎症的抑制和免疫反应的调节可能是预防NDD发展的有效方法。NSAIDs以不同方式影响PD神经病理学可能产生有益或有害影响。NSAIDs对环氧合酶2（COX2）的抑制可能预防PD的发展。NSAIDs通过调节神经炎症对PD神经病理学的发展和进展起到神经保护作用。然而，NSAIDs可能通过抑制神经保护性前列环素（PGI2）和加重促炎性白三烯（LTs）而导致中性或有害影响。总之，关于NSAIDs对PD神经病理学的影响仍然存在潜在冲突。
