黏附环：侵袭性伪足与免疫突触的结构比较
Adhesions ring: a structural comparison between podosomes and the immune synapse.
作者信息
Wernimont Sarah A, Cortesio Christa L, Simonson William T N, Huttenlocher Anna
机构信息
Program in Cellular and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA.
出版信息
Eur J Cell Biol. 2008 Sep;87(8-9):507-15. doi: 10.1016/j.ejcb.2008.01.011. Epub 2008 Mar 17.
Abstract
Podosomes and the immune synapse are integrin-mediated adhesive structures that share a common ring-like morphology. Both podosomes and immune synapses have a central core surrounded by a peripheral ring containing talin, vinculin and paxillin. Recent progress suggests significant parallels between the regulatory mechanisms that contribute to the formation of these adhesive structures. In this review, we compare the structures, functions and regulation of podosomes and the immune synapse.
摘要
足体和免疫突触是整合素介导的黏附结构，具有共同的环状形态。足体和免疫突触都有一个中央核心，周围是一个包含踝蛋白、纽蛋白和桩蛋白的外周环。最近的研究进展表明，在促成这些黏附结构形成的调控机制之间存在显著的相似之处。在这篇综述中，我们比较了足体和免疫突触的结构、功能及调控。
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