Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), Via Morego, 16163 Genova, Italy.
Department of Electrical, Electronic, Telecommunications Engineering and Naval Architecture, University of Genova, Via Opera Pia, 11a, 16145 Genova, Italy.
Biosensors (Basel). 2022 May 30;12(6):375. doi: 10.3390/bios12060375.
A rapid point-of-care method for the colorimetric detection of cisplatin was developed, exploiting the efficient conversion of the chemotherapeutic drug into a high-performance nanocatalyst with peroxidase enzyme mimics. This assay provides high specificity and ppb-detection sensitivity with the naked eye or a smartphone-based readout, outperforming many standard laboratory-based techniques. The nanocatalyst-enabled colorimetric assay can be integrated with machine-learning methods, providing accurate quantitative measurements. Such a combined approach opens interesting perspectives for the on-site monitoring of both chemotherapeutic patients to achieve optimal treatments and healthcare workers to prevent their unsafe exposure.
开发了一种用于顺铂比色检测的快速即时检测方法，利用将化疗药物高效转化为具有过氧化物酶模拟物的高性能纳米催化剂。该测定法具有高特异性和肉眼或基于智能手机的读出的 ppb 检测灵敏度，优于许多标准实验室技术。纳米催化剂增强的比色测定法可以与机器学习方法集成，提供准确的定量测量。这种组合方法为现场监测化疗患者以实现最佳治疗以及医护人员预防其不安全暴露提供了有趣的前景。
