Werbrouck Bart F, Pauwels Walter J, De Bleecker Jan L
Department of Neurology, Ghent University Hospital, Ghent, Belgium.
Clin Toxicol (Phila). 2008 Mar;46(3):264-6. doi: 10.1080/15563650701438763.
The standard adjuvant therapy for rectal cancer is 5-fluorouracil (5-FU) often combined with radiotherapy. Well-documented side effects of 5-FU include nausea, vomiting and diarrhoea, leukopenia and thrombocytopenia, hand-foot syndrome, mucositis, and cardiotoxicity. Peripheral neurotoxicity has only rarely been reported. We report a patient with a stage II rectal carcinoma who developed a mild axonal sensorimotor neuropathy at the end of a 5-FU therapy.
直肠癌的标准辅助治疗方法是使用5-氟尿嘧啶（5-FU），通常联合放疗。5-FU有充分文献记载的副作用包括恶心、呕吐、腹泻、白细胞减少和血小板减少、手足综合征、粘膜炎以及心脏毒性。外周神经毒性仅有极少病例报告。我们报告1例II期直肠癌患者，在5-FU治疗结束时出现轻度轴索性感觉运动神经病。
