Kuipers H, Van't Hullenaar G A C, Pluim B M, Overbeek S E, De Hon O, Van Breda E J, Van Loon L C
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), University of Maastricht, Maastricht, The Netherlands.
Br J Sports Med. 2008 Nov;42(11):868-71. doi: 10.1136/bjsm.2007.042572. Epub 2008 Mar 14.
To assess possible ergogenic properties of corticosteroid administration.
A balanced, double-blind, placebo-controlled design was used.
28 well-trained cyclists and rowers.
4 weeks' daily inhalation of 800 microg budesonide or placebo.
The subjects performed three incremental cycle ergometer tests until exhaustion, before and after 2 and 4 weeks of placebo or budesonide administration, to measure maximal power output (W(max)). Once a week they filled in a profile of mood state (POMS) questionnaire.
There was no significant difference in W(max) between the placebo (376 (SD 25) W) and the corticosteroid group (375 (36) W) during the preintervention test, and there were no significant changes in either group after 2 and 4 weeks of intervention. No effect of the intervention on mood state was found.
4 weeks of corticosteroid or placebo inhalation in healthy, well-trained athletes did not affect maximal power output or mood state. Hence no ergogenic properties of 4 weeks' corticosteroid administration could be demonstrated, which corroborates previous studies of short-term corticosteroid administration.
评估使用皮质类固醇可能产生的促力特性。
采用平衡、双盲、安慰剂对照设计。
28名训练有素的自行车运动员和赛艇运动员。
每天吸入800微克布地奈德或安慰剂，为期4周。
在给予安慰剂或布地奈德2周和4周前后，受试者进行三次递增式自行车测力计测试直至力竭，以测量最大功率输出（W(max)）。他们每周填写一次情绪状态量表（POMS）问卷。
干预前测试时，安慰剂组（376（标准差25）瓦）和皮质类固醇组（375（36）瓦）的W(max)无显著差异，干预2周和4周后两组均无显著变化。未发现干预对情绪状态有影响。
在健康、训练有素的运动员中，吸入皮质类固醇或安慰剂4周对最大功率输出或情绪状态无影响。因此，无法证明给予皮质类固醇4周具有促力特性，这与先前关于短期给予皮质类固醇的研究结果一致。
