一名儿童同时使用多种抗惊厥药物时出现的毒性反应。
Simultaneous toxicities in a child on multiple anticonvulsants.
作者信息
Delima Sarah Isis R, Walsh Laurence E, Golomb Meredith R
机构信息
Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
出版信息
J Child Neurol. 2008 Sep;23(9):1054-7. doi: 10.1177/0883073808314156. Epub 2008 Mar 14.
It is rare to develop simultaneous toxicities while on anticonvulsants. This article presents a 3(1/2)-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection. These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam. This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.
在服用抗惊厥药物期间同时出现毒性反应的情况较为罕见。本文介绍了一名3岁半的儿童，正在服用丙戊酸、拉莫三嗪和苯妥英钠，在感染3型副流感病毒期间同时出现了肝毒性和骨髓毒性。停用抗惊厥药物后，这些毒性反应得到缓解，她的癫痫发作通过定期使用劳拉西泮进行了紧急处理。本文讨论了同时使用丙戊酸、拉莫三嗪和苯妥英钠可能导致这种毒性组合的可能性，以及并发病毒感染可能会增加这种风险。
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