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静脉注射免疫球蛋白与血浆置换作为重症肌无力术前治疗方法的疗效比较。

A comparison of the effectiveness of intravenous immunoglobulin and plasma exchange as preoperative therapy of myasthenia gravis.

作者信息

Jensen Paul, Bril Vera

机构信息

University Health Network, University of Toronto, Toronto, Canada.

出版信息

J Clin Neuromuscul Dis. 2008 Mar;9(3):352-5. doi: 10.1097/CND.0b013e3181660807.

DOI:10.1097/CND.0b013e3181660807
PMID:18344718
Abstract

OBJECTIVES

Immunomodulation with plasma exchange is effective in preparing patients for thymectomy. Newer forms of immunomodulation, such as intravenous immunomodulation, require evaluation in this clinical setting.

METHODS

We conducted a retrospective chart review to determine if plasma exchange and intravenous immunoglobulin had comparable effectiveness in the preoperative preparation of patients with myasthenia gravis.

RESULTS AND CONCLUSIONS

The results show that intravenous immunoglobulin may have comparable efficacy in the preoperative preparation of patients with myasthenia gravis and that this therapy is a reasonable alternative to plasma exchange in this clinical setting.

摘要

目的

血浆置换免疫调节疗法对患者胸腺切除术的术前准备有效。新型免疫调节疗法,如静脉免疫调节疗法,需要在此临床环境中进行评估。

方法

我们进行了一项回顾性病历审查,以确定血浆置换和静脉注射免疫球蛋白在重症肌无力患者术前准备中的有效性是否相当。

结果与结论

结果表明,静脉注射免疫球蛋白在重症肌无力患者术前准备中可能具有相当的疗效,并且在这种临床环境中,该疗法是血浆置换的合理替代方案。

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