由奥氮平和阿立哌唑引起的光甲剥离症。
Photo-onycholysis caused by olanzapine and aripiprazole.
作者信息
Gregoriou Stamatis, Karagiorga Theodora, Stratigos Alexander, Volonakis Kyriakos, Kontochristopoulos George, Rigopoulos Dimitris
机构信息
Department of Dermatology, University of Athens, A. Sygros Hospital, Athens, Greece.
出版信息
J Clin Psychopharmacol. 2008 Apr;28(2):219-20. doi: 10.1097/JCP.0b013e318166c50a.
Photo-onycholysis associated with drugs is an uncommon disorder. We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine. Substitution of olanzapine with aripiprazole further exacerbated the problem. The possible mechanisms of photo-onycholysis development by modern atypical antipsychotics, modulating dopamine receptors, are discussed.
药物相关性光甲脱离是一种罕见的疾病。我们报告了一例女性患者，在服用奥氮平后多个指甲出现光甲脱离。用阿立哌唑替代奥氮平进一步加重了问题。本文讨论了现代非典型抗精神病药物通过调节多巴胺受体导致光甲脱离的可能机制。
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