Oztürk Faruk, Yavas Güliz Fatma, Küsbeci Tuncay, Ermis Sitki Samet
Faculty of Medicine, Department of Ophthalmology, Afyon Kocatepe University, Afyonkarahisar, Turkey.
J Glaucoma. 2008 Mar;17(2):118-21. doi: 10.1097/IJG.0b013e31814b97fd.
It is known that macula can be affected adversely in glaucoma. In this study, we aimed to evaluate the functional and morphologic changes of macula in patients having glaucoma using Microperimeter-1 (MP-1), Humphrey field analyzer (HFA), and Heidelberg Retina Tomograph II (HRT-II).
This prospective study consisted of 43 patients having primary open angle glaucoma. Control group consisted of 26 normal cases. Macular threshold was evaluated with HFA macula threshold test and MP-1 Humphrey macula pattern. Morphometric evaluation of macula was performed with HRT-II. The results were evaluated by independent samples t test and receiver operator curves.
Macular sensitivity was lower in patients having glaucoma with both HFA and MP-1 in all quadrants (P=0.003 for HFA and P=0.002 for MP-1). The macular thickness measurements obtained with HRT-II was not significant between glaucoma patients and control group (P=0.153). The difference between HFA and MP-1, HFA and HRT-II, MP-1 and HRT-II was not statistically significant (P=0.302, 0.110, and 0.481, respectively).
Perimetric macular changes can occur while macular topographic remains stable in patients with glaucoma. MP-1 correlates with HFA in detecting glaucomatous visual field defect in macular area.
已知青光眼可对黄斑产生不良影响。在本研究中,我们旨在使用微视野计-1(MP-1)、汉弗莱视野分析仪(HFA)和海德堡视网膜断层扫描仪II(HRT-II)评估青光眼患者黄斑的功能和形态变化。
这项前瞻性研究纳入了43例原发性开角型青光眼患者。对照组由26例正常受试者组成。使用HFA黄斑阈值测试和MP-1汉弗莱黄斑模式评估黄斑阈值。使用HRT-II对黄斑进行形态学评估。结果通过独立样本t检验和受试者操作曲线进行评估。
青光眼患者在所有象限中,HFA和MP-1测量的黄斑敏感度均较低(HFA为P = 0.003,MP-1为P = 0.002)。青光眼患者和对照组之间,HRT-II测量的黄斑厚度无显著差异(P = 0.153)。HFA与MP-1、HFA与HRT-II、MP-1与HRT-II之间的差异无统计学意义(分别为P = 0.302、0.110和0.481)。
青光眼患者黄斑地形图保持稳定时,视野检查可出现黄斑变化。在检测黄斑区青光眼性视野缺损方面,MP-1与HFA具有相关性。