Lebre Maria C, Tak Paul P
Academic Medical Center, University of Amsterdam, Division of Clinical Immunology and Rheumatology, Amsterdam, The Netherlands.
Acta Reumatol Port. 2008 Jan-Mar;33(1):35-45.
Dendritic cells (DC) are now known to influence many different classes of lymphocytes (T, B, NK cells) and many types of T cell responses (Th1/Th2/Th17, regulatory T cells, peripheral T cell deletion). In rheumatoid arthritis (RA) DC have been described and their roles in RA pathogenesis have been implicated. This review summarizes the data obtained so far concerning the functional characterization of several DC subsets in human RA. Moreover, the effect of TNF-alpha blockade on DC phenotype and function is also discussed. As most of the studies on DC in experimental arthritis have been conducted using (immunomodulated/tolerogenic) DC as tools to ameliorate experimental arthritis, we give some examples of how these cells may induce tolerance in vivo. Although a lot of work has been performed so far, the specific and functional roles of DC subsets in human RA and in CIA remain to be established. Achieving a detailed understanding of specific DC functions in RA holds potential for modulating DC for immunotherapy by down-regulating the autoimmune response.
目前已知树突状细胞（DC）可影响许多不同类型的淋巴细胞（T细胞、B细胞、NK细胞）以及多种T细胞应答（Th1/Th2/Th17、调节性T细胞、外周T细胞缺失）。在类风湿关节炎（RA）中，DC已被描述，并且其在RA发病机制中的作用也已被提及。本综述总结了迄今为止获得的有关人类RA中几种DC亚群功能特征的数据。此外，还讨论了肿瘤坏死因子-α（TNF-α）阻断对DC表型和功能的影响。由于大多数关于实验性关节炎中DC的研究都是使用（免疫调节性/耐受性）DC作为改善实验性关节炎的工具进行的，因此我们给出了一些这些细胞如何在体内诱导耐受性的例子。尽管迄今为止已经开展了大量工作，但DC亚群在人类RA和胶原诱导性关节炎（CIA）中的具体和功能作用仍有待确定。深入了解RA中特定DC的功能对于通过下调自身免疫反应来调节DC进行免疫治疗具有潜在意义。
