Sweat V, Starr V, Bruehl H, Arentoft A, Tirsi A, Javier E, Convit A
Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.
Inflammation. 2008 Jun;31(3):198-207. doi: 10.1007/s10753-008-9065-3. Epub 2008 Mar 18.
Our objective was to ascertain the nature of the associations between C-reactive protein (CRP) and cognition, and to examine how they are affected by gender and obesity. We evaluated 62 females and 63 males between 42 and 82 years of age. There were 20 lean females with a body mass index (BMI) of <25 kg/m2 and 42 overweight or obese females, with BMIs > or =25 kg/m2. There were 14 lean males and 49 with BMIs >/=25 kg/m2. CRP was associated with lower scores on cognitive tests of frontal lobe function among females and these associations were driven by the overweight/obese female group. In these data no associations between CRP and cognition were found among males. Obesity-associated inflammation is much more prominent in females and it appears to be associated with cognitive dysfunction, particularly of frontal lobe tasks.
我们的目标是确定C反应蛋白（CRP）与认知之间关联的性质，并研究性别和肥胖如何影响这些关联。我们评估了62名42至82岁的女性和63名男性。有20名体重指数（BMI）<25 kg/m²的瘦女性和42名BMI≥25 kg/m²的超重或肥胖女性。有14名瘦男性和49名BMI≥25 kg/m²的男性。CRP与女性额叶功能认知测试得分较低相关，这些关联由超重/肥胖女性组驱动。在这些数据中，未发现男性中CRP与认知之间存在关联。肥胖相关炎症在女性中更为突出，并且似乎与认知功能障碍有关，特别是额叶任务方面。
