Ye Xingwang, Yu Zhijie, Li Huaixing, Franco Oscar H, Liu Yong, Lin Xu
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China.
J Am Coll Cardiol. 2007 May 1;49(17):1798-805. doi: 10.1016/j.jacc.2007.01.065. Epub 2007 Apr 16.
We evaluated the distributions of C-reactive protein (CRP) and its association with metabolic syndrome (MetS) in middle-aged and older Chinese people.
Several studies have suggested that CRP is a risk factor of MetS. However, it remains unclear how CRP levels are distributed and whether they are associated with MetS in Chinese people.
We conducted a population-based cross-sectional survey in 2005 in Beijing and Shanghai, with a total of 1,458 men and 1,831 women age 50 to 70 years. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.
The median CRP level was 0.68 mg/l among the study population. The CRP levels were significantly higher among participants from Beijing or from urban areas than those in participants from Shanghai or from rural areas (p < 0.01). No gender difference in CRP levels was observed. The prevalence of MetS progressively increased with elevated CRP levels (p < 0.0001 for trend). In the highest quartile of CRP levels (>1.50 mg/l), the risk for MetS was substantially higher (odds ratio 5.97; 95% confidence interval 4.75 to 7.51) compared with that in the lowest quartile of CRP levels (< or =0.33 mg/l) after adjustment for age, gender, geographic location, lifestyle factors, educational attainment, and family history of chronic diseases. This association was observed in both obese and nonobese participants.
The overall plasma level of CRP is low but highly associated with the MetS among the middle-aged and elderly Chinese population. Prospective studies are needed to investigate the role of CRP in the development of MetS and related chronic diseases among Chinese people.
我们评估了中国中老年人中C反应蛋白（CRP）的分布情况及其与代谢综合征（MetS）的关联。
多项研究表明CRP是MetS的一个危险因素。然而，CRP水平在中国人群中如何分布以及它们是否与MetS相关仍不清楚。
2005年我们在北京和上海进行了一项基于人群的横断面调查，共有1458名年龄在50至70岁的男性和1831名女性参与。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告针对亚裔美国人的更新标准进行定义。
研究人群中CRP水平的中位数为0.68mg/l。北京或城市地区参与者的CRP水平显著高于上海或农村地区参与者（p<0.01）。未观察到CRP水平存在性别差异。MetS的患病率随CRP水平升高而逐渐增加（趋势p<0.0001）。在CRP水平最高的四分位数组（>1.50mg/l）中，在对年龄、性别、地理位置、生活方式因素、教育程度和慢性疾病家族史进行调整后，与CRP水平最低的四分位数组（≤0.33mg/l）相比，MetS的风险显著更高（优势比5.97；95%置信区间4.75至7.51）。在肥胖和非肥胖参与者中均观察到这种关联。
中国中老年人群中CRP的总体血浆水平较低，但与MetS高度相关。需要进行前瞻性研究以调查CRP在中国人群中MetS及相关慢性疾病发生发展中的作用。
