Xie Jingwu
Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1048, USA.
Adv Exp Med Biol. 2008;624:241-51. doi: 10.1007/978-0-387-77574-6_19.
Basal cell carcinomas and Squamous cell carcinomas are the two most common human cancers. The incidence of these two types of cancer is estimated to double within 20 years. Identification of the key molecular events is critical in helping us design novel strategies to treat and to prevent these cancers. For example, identification of hedgehog signaling activation has opened up many opportunities for targeted therapy and prevention of basal cell carcinomas. Significant progress has also been made in our understanding of squamous cell carcinomas of the skin. In this chapter, we will focus on major recent developments in our understanding of basal cell carcinomas and squamous cell carcinomas at the molecular levels and their clinical implications.
基底细胞癌和鳞状细胞癌是人类最常见的两种癌症。据估计，这两种癌症的发病率在20年内将翻一番。识别关键分子事件对于帮助我们设计治疗和预防这些癌症的新策略至关重要。例如，刺猬信号通路激活的识别为基底细胞癌的靶向治疗和预防开辟了许多机会。我们对皮肤鳞状细胞癌的认识也取得了重大进展。在本章中，我们将重点关注近年来在分子水平上对基底细胞癌和鳞状细胞癌的认识及其临床意义的主要进展。
