Department of Dermatology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Cancer. 2023 Mar 15;129(6):836-844. doi: 10.1002/cncr.34635. Epub 2023 Jan 16.
Although much attention has been devoted to a detailed genomic exposition of cutaneous melanoma, other nonmelanoma skin cancers have also recently been subjected to similar analytical scrutiny. Chief among these are the most common malignancies worldwide: basal cell carcinomas and cutaneous squamous cell carcinomas. In this review, the authors summarize their latest knowledge about the molecular pathways and therapeutic opportunities attendant to these keratinocytic skin cancers. PLAIN LANGUAGE SUMMARY: The most common cancers in the United States arise from skin cells called keratinocytes. Although these tumors are not formally tracked by the National Cancer Institute, it is estimated that there are millions of skin cancers called basal cell carcinomas and squamous cell carcinomas. This article reviews the current recent genetic insights into these tumors and therapeutic opportunities.
虽然人们已经对皮肤黑色素瘤进行了详细的基因组阐述，但最近其他非黑色素瘤皮肤癌也受到了类似的分析研究。其中最重要的是全球最常见的恶性肿瘤：基底细胞癌和皮肤鳞状细胞癌。在这篇综述中，作者总结了他们对这些角质细胞皮肤癌相关分子途径和治疗机会的最新认识。
