大鼠运动至力竭后内皮素和心钠素的变化

Endothelin and atrial natriuretic peptide after exercise performed until exhaustion in the rat.

作者信息

Allevard A M, Gauquelin G, Gharib C

机构信息

Lab. Physiologie de l'Environnement, Fac. Med. Grange-Blanche, Lyon, France.

出版信息

Life Sci. 1991;49(24):1803-8. doi: 10.1016/0024-3205(91)90481-p.

DOI:10.1016/0024-3205(91)90481-p

PMID:1834901

Abstract

Endothelin-1(ET) is a recently discovered endothelium-derived vasoconstrictor peptide. Plasma concentrations of immunoreactive (IR-) endothelin were investigated in rats by radioimmunoassay after extraction of endothelin on Sep-Pak Cartridges. In control rats, a mean concentration of 1.03 +/- 0.2 pg/ml was found. After exercise performed until semi-exhaustion or exhaustion, the mean plasma concentration of IR-endothelin decreased. An increase of Atrial Natriuretic Peptide plasma was observed immediately after exercise. There was a negative correlation between Endothelin and Atrial Natriuretic Peptide (r = -0.73, p less than 0.001). This is the first time that this increase following exercise is shown in normotensive rat. The mechanisms of the decrease of Endothelin are unclear. One hypothesis could be that the decrease in Endothelin is related to its rapid removal by the different tissues, specially the lungs.

摘要

内皮素-1（ET）是最近发现的一种内皮源性血管收缩肽。在用Sep-Pak柱提取内皮素后，通过放射免疫分析法对大鼠血浆中免疫反应性（IR-）内皮素的浓度进行了研究。在对照大鼠中，发现平均浓度为1.03±0.2 pg/ml。进行运动直至半疲劳或疲劳后，IR-内皮素的平均血浆浓度降低。运动后立即观察到心房利钠肽血浆水平升高。内皮素与心房利钠肽之间存在负相关（r = -0.73，p < 0.001）。这是首次在正常血压大鼠中显示运动后出现这种升高。内皮素降低的机制尚不清楚。一种假设可能是内皮素的降低与其被不同组织，特别是肺快速清除有关。