Bekki Kanae, Tang Ning, Toriba Akira, Hayakawa Kazuichi
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
J UOEH. 2008 Mar 1;30(1):39-45. doi: 10.7888/juoeh.30.39.
Airborne particulate matters contain many kinds of organic pollutants. Among them, polycyclic aromatic hydrocarbons (PAH), nitropolycyclic aromatic hydrocarbons (NPAH) and quinoid PAHs were reported to have several human health effects. We collected airborne particulates in Kitakyushu, Japan and Tieling, China in summer and winter, and analyzed the PAH and NPAH to evaluate the direct- and indirect-acting mutagenicities and generating activities of reactive oxygen species (ROS). The concentrations of PAHs and NPAHs in Tieling were much higher than in Kitakyushu, with seasonal variations. The mutagenicity level was higher in winter while the ROS generation activity was higher in summer. These results suggest that concentrations of PAH and NPAH didn't correlate with mutagenicity and ROS generation activity. More studies are needed on the environmental behaviors of compounds other than PAHs and NPAHs, such as quinoid PAHs, and their biological activities.
空气中的颗粒物含有多种有机污染物。其中，据报道多环芳烃（PAH）、硝基多环芳烃（NPAH）和醌类多环芳烃对人体健康有多种影响。我们于夏季和冬季在日本北九州和中国铁岭采集了空气颗粒物，并分析了PAH和NPAH，以评估其直接和间接作用的诱变性以及活性氧（ROS）的生成活性。铁岭的PAH和NPAH浓度远高于北九州，且存在季节性变化。诱变性水平在冬季较高，而ROS生成活性在夏季较高。这些结果表明，PAH和NPAH的浓度与诱变性和ROS生成活性无关。对于除PAH和NPAH之外的化合物，如醌类多环芳烃及其生物活性的环境行为，还需要进行更多研究。
