Eiskjaer H, Mogensen C E, Schmitz A, Pedersen E B
Department of Medicine and Nephrology C, Skejby Hospital, Denmark.
Scand J Clin Lab Invest. 1991 Jun;51(4):359-66. doi: 10.1080/00365519109091627.
Atrial natriuretic peptide (ANP) was given as an intravenous bolus injection (2.0 micrograms kg-1) to 12 essential hypertensive patients (EH) and 10 normotensive control subjects (C) in order to study the effect of ANP on urinary excretion of albumin and beta 2-microglobulin, and on glomerular filtration rate (GFR), renal plasma flow (RPF), and filtration fraction (FF). After the ANP injection, urinary excretion of albumin increased significantly (p less than 0.01) in EH from 7.3 micrograms min to 125 micrograms min (medians) and in C from 2.9 micrograms min-1 to 8.1 micrograms min-1 (p less than 0.05). Urinary excretion of beta 2-microglobulin increased in EH from 70 ng min-1 to 1022 ng min-1 (p less than 0.01) and in C from 118 ng min-1 to 170 ng min-1 (p less than 0.01). The increase in urinary excretion of both albumin (p less than 0.01) and B2-microglobulin (p less than 0.01) was significantly more pronounced in EH than in C. GFR and RPF were almost unchanged in both groups. FF rose to the same degree in the two groups. The increase in fractional excretion of sodium and in urine volume after ANP was enhanced in EH. It is concluded that ANP in pharmacological doses increased urinary excretion of albumin and beta 2-microglobulin to a considerably larger extent in essential hypertensive patients than in normotensive control subjects.
对12例原发性高血压患者（EH）和10例血压正常的对照者（C）静脉推注心房利钠肽（ANP，2.0微克/千克），以研究ANP对白蛋白和β2-微球蛋白尿排泄、肾小球滤过率（GFR）、肾血浆流量（RPF）及滤过分数（FF）的影响。注射ANP后，EH患者的白蛋白尿排泄量从7.3微克/分钟显著增加至125微克/分钟（中位数）（p<0.01），C组从2.9微克/分钟增加至8.1微克/分钟（p<0.05）。EH患者的β2-微球蛋白尿排泄量从70纳克/分钟增加至1022纳克/分钟（p<0.01），C组从118纳克/分钟增加至170纳克/分钟（p<0.01）。EH患者白蛋白（p<0.01）和β2-微球蛋白（p<0.01）尿排泄量的增加均显著高于C组。两组的GFR和RPF几乎未变。两组的FF升高程度相同。EH患者ANP后钠排泄分数和尿量的增加更为明显。得出结论，药理剂量的ANP使原发性高血压患者白蛋白和β2-微球蛋白的尿排泄量增加的幅度远大于血压正常的对照者。
