Suppr超能文献

母乳喂养:婴幼儿脑室腹腔分流术感染的潜在保护因素。

Breastfeeding: a potential protective factor against ventriculoperitoneal shunt infection in young infants.

作者信息

Nejat Farideh, Tajik Parvin, Ghodsi Syed Mohammad, Golestan Banafsheh, Majdzadeh Reza, Yazdani Shahrooz, Ansari Saeed, Dadmehr Majid, Ganji Sara, Najafi Mehri, Farahmand Fatemeh, Moatamed Farzaneh

机构信息

Department of Neurosurgery, Children's Hospital Medical Center, and Department of Epidemiology and Biostatistics, School of Public Health, University of Tehran, Iran.

出版信息

J Neurosurg Pediatr. 2008 Feb;1(2):138-41. doi: 10.3171/PED/2008/1/2/138.

Abstract

OBJECT

Previous studies have shown nutritional benefits of breastfeeding for a child's health, especially for protection against infection. Protective factors in human milk locally and systemically prevent infections in the gastrointestinal as well as upper and lower respiratory tracts. It remains unclear whether breastfeeding protects infants against ventriculoperitoneal (VP) shunt infection.

METHODS

A cohort study was conducted from December 2003 to December 2006 at Children's Hospital Medical Center in Tehran, Iran. A total of 127 infants with hydrocephalus who were treated using a VP shunt in the first 6 months of life were enrolled. Each infant's breastfeeding method was classified as either exclusively breastfed (EBF), combination feedings of breast milk and formula (CFBF), or exclusively formula-fed (EFF). Infants were followed up to determine the occurrence of shunt infection within 6 months after operation. Statistical analysis was performed using survival methods.

RESULTS

Infants ranged in age from 4 to 170 days at the time of shunt insertion (mean 69.6 days), and 57% were males. Regarding the breastfeeding categories, 57.5% were EBF, 25.2% were CFBF, and 17.3% were EFF. During the follow-up, shunt infection occurred in 16 patients, within 15 to 173 days after shunt surgery (median 49 days). The 6-month risk of shunt infection was 8.5% (95% confidence interval [CI] 4-18%) in the EBF group, 16.5% (95% CI 7-35%) in the CFBF group, and 26.0% (95% CI 12-52%) in the EFF group. There was no statistically significant difference between these 3 groups (p=0.11). The trend test showed a significant trend between the extent of breastfeeding and the risk of shunt infection (p=0.035), which persisted even after adjustment for potential confounding variables (hazard ratio=2.01, 95% CI 1.01-4).

CONCLUSIONS

This study supports the protective effect of breastfeeding against shunt infection during the first 6 months of life and the presence of a dose-response relationship, such that the higher the proportion of an infant's feeding that comes from human milk, the lower the incidence of shunt infection. Encouraging mothers of infants with VP shunts to breastfeed exclusively in the first 6 months of life is recommended.

摘要

目的

以往研究表明母乳喂养对儿童健康具有营养益处,尤其是在预防感染方面。母乳中的保护因子可在局部和全身预防胃肠道以及上、下呼吸道感染。母乳喂养是否能保护婴儿预防脑室腹腔(VP)分流感染仍不清楚。

方法

2003年12月至2006年12月在伊朗德黑兰儿童医院医学中心进行了一项队列研究。共纳入127例在出生后前6个月接受VP分流治疗的脑积水婴儿。每个婴儿的喂养方式分为纯母乳喂养(EBF)、母乳与配方奶混合喂养(CFBF)或纯配方奶喂养(EFF)。对婴儿进行随访以确定术后6个月内分流感染的发生情况。采用生存方法进行统计分析。

结果

分流置入时婴儿年龄在4至170天之间(平均69.6天),57%为男性。在母乳喂养类别方面,57.5%为EBF,25.2%为CFBF,17.3%为EFF。随访期间,16例患者发生分流感染,发生在分流手术后15至173天(中位数49天)。EBF组6个月分流感染风险为8.5%(95%置信区间[CI]4 - 18%),CFBF组为16.5%(95%CI 7 - 35%),EFF组为26.0%(95%CI 12 - 52%)。这3组之间无统计学显著差异(p = 0.11)。趋势检验显示母乳喂养程度与分流感染风险之间存在显著趋势(p = 0.035),即使在对潜在混杂变量进行调整后该趋势仍然存在(风险比 = 2.01,95%CI 1.01 - 4)。

结论

本研究支持母乳喂养在出生后前6个月对分流感染的保护作用以及剂量反应关系的存在,即婴儿来自母乳的喂养比例越高,分流感染发生率越低。建议鼓励患有VP分流的婴儿母亲在婴儿出生后前6个月进行纯母乳喂养。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验