Chihara J, Nakano N, Kurachi D, Seguchi M, Mouri T, Uenishi H, Nakajima S
Fourth Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.
Ann Allergy. 1991 Oct;67(4):429-32.
The present study was designed to clarify whether Fc epsilon R2 can be induced on lymphocytes of patients with bronchial asthma by stimulation with specific antigen. Expression of Fc epsilon R2 on freshly isolated lymphocytes (at 0 hour) was significantly higher in both patients with mite-allergic asthma and those with nonmite-atopic asthma than in healthy individuals. In addition, expression of Fc epsilon R2 on lymphocytes was still higher in patients during acute asthma. Marked induction of Fc epsilon R2 on lymphocytes was observed 48 hours or more after addition of mite-allergen in patients with mite-allergic asthma while no Fc epsilon R2 expression was induced in patients with nonmite-atopic asthma or healthy individuals. Induction of Fc epsilon R2 expression was not observed at 30 minutes, two hours, and five hours, which are equivalent in kinetics to immediate asthmatic response and late asthmatic response in allergen inhalational challenges.
本研究旨在阐明支气管哮喘患者的淋巴细胞经特异性抗原刺激后是否可诱导表达FcεR2。在刚分离的淋巴细胞（0小时）上，螨过敏性哮喘患者和非螨特应性哮喘患者的FcεR2表达均显著高于健康个体。此外，急性哮喘患者淋巴细胞上的FcεR2表达仍然较高。在螨过敏性哮喘患者中，添加螨过敏原后48小时或更长时间观察到淋巴细胞上FcεR2的明显诱导，而非螨特应性哮喘患者或健康个体未诱导出FcεR2表达。在30分钟、2小时和5小时未观察到FcεR2表达的诱导，这些时间点在动力学上等同于过敏原吸入激发试验中的速发型哮喘反应和迟发型哮喘反应。
