Carreño M, Gil-Nagel A, Sánchez J C, Elices E, Serratosa J M, Salas-Puig J, Villanueva V, Porcel J
Epilepsy Unit, Neurology Service, Hospital Clinic i Provincial, Barcelona, Spain.
Epilepsy Behav. 2008 Jul;13(1):178-83. doi: 10.1016/j.yebeh.2008.02.006. Epub 2008 Mar 18.
The aim was to study the frequency and types of adverse effects (AEs) in patients treated with antiepileptic drugs (AEDs) according to the strategies used by the neurologist to detect them.
This cross-sectional epidemiological study was carried out in standard clinical practice. Two strategies were used to detect AEs: spontaneous reporting by the patient, and a checklist of possible treatment-related adverse reactions completed by the patient.
A total of 579 patients were recruited for the study. Roughly a third (33.7%) reported AEs spontaneously, and 65.2% did so when administered the checklist. The main reason for changing medication was lack of efficacy, but significant side effects were also an important reason for modifying treatment in those patients who reported higher levels of discomfort.
The use of an active approach is recommended for detection of AEs of AED treatment. AEs appear to have a key effect on the decision to change treatment.
根据神经科医生用于检测不良反应的策略，研究接受抗癫痫药物（AED）治疗的患者中不良反应（AE）的发生频率和类型。
本横断面流行病学研究在标准临床实践中进行。采用两种策略检测AE：患者自发报告，以及患者填写的与治疗相关的可能不良反应清单。
共招募了579名患者进行研究。约三分之一（33.7%）的患者自发报告了AE，而在使用清单时，这一比例为65.2%。换药的主要原因是疗效不佳，但对于报告不适感较高的患者，严重副作用也是改变治疗的重要原因。
建议采用积极的方法检测AED治疗的AE。AE似乎对治疗决策有关键影响。
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