镍催化碳酸烯丙酯与高烯丙醇通过逆烯丙基化反应生成1,5-己二烯。
Nickel-catalyzed allylation of allyl carbonates with homoallyl alcohols via retro-allylation providing 1,5-hexadienes.
作者信息
Sumida Yuto, Hayashi Sayuri, Hirano Koji, Yorimitsu Hideki, Oshima Koichiro
机构信息
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto, Japan.
出版信息
Org Lett. 2008 Apr 17;10(8):1629-32. doi: 10.1021/ol800335v. Epub 2008 Mar 21.
PMID:18355073
Abstract
A highly efficient and mild method for the synthesis of 1,5-hexadienes, nickel-catalyzed reactions of Boc-protected allyl alcohols with homoallyl alcohols, has been developed. Nickel-mediated retro-allylation allows for the use of homoallyl alcohols as allylmetal equivalents in the synthesis of 1,5-hexadienes.
摘要
已开发出一种高效温和的合成1,5 - 己二烯的方法，即镍催化Boc保护的烯丙醇与高烯丙醇的反应。镍介导的逆烯丙基化反应使得在1,5 - 己二烯的合成中可以使用高烯丙醇作为烯丙基金属等价物。
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