Henke Andreas, Jarasch Nadine, Martin Ulrike, Zell Roland, Wutzler Peter
Institute of Virology and Antiviral Therapy, Medical Center, Friedrich Schiller University, Jena, Germany.
Viral Immunol. 2008 Mar;21(1):38-48. doi: 10.1089/vim.2007.0077.
Several different procedures have been developed to deliver essential genes to an organism by viral vectors. Some reports have already been published demonstrating the potential to use enteroviruses as transfer vehicles. One application of these viral vectors is the organ-specific expression of immunoregulatory cytokines. It has been shown previously that local expression of interferon-gamma (IFN-gamma) by the recombinant coxsackievirus CVB3/IFN-gamma conferred protection against virus-caused disease via direct and indirect mechanisms. Using a murine model of CVB3-induced myocarditis, other aspects of the CVB3/IFN-gamma application as a vaccine were studied concerning route of administration, age, and presence of a pre-existing immune response.
已经开发出几种不同的程序，通过病毒载体将必需基因传递给生物体。已经发表了一些报告，证明了使用肠道病毒作为传递载体的潜力。这些病毒载体的一个应用是免疫调节细胞因子的器官特异性表达。先前已经表明，重组柯萨奇病毒CVB3/干扰素-γ（IFN-γ）在局部表达干扰素-γ可通过直接和间接机制预防病毒引起的疾病。利用CVB3诱导的心肌炎小鼠模型，研究了CVB3/IFN-γ作为疫苗应用的其他方面，包括给药途径、年龄和预先存在的免疫反应。
