Rankin J W, Andreae M C, Oliver Chen C-Y, O'Keefe S F
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24061-0430, USA.
Diabetes Obes Metab. 2008 Nov;10(11):1086-96. doi: 10.1111/j.1463-1326.2008.00867.x. Epub 2008 Mar 18.
Oxidative stress can initiate increased inflammation that elevates risk for cardiovascular disease. The objective of this study was to determine the effects of daily consumption of raisins on markers of oxidative stress, inflammation and endothelial activation in response to an acute high-fat meal in overweight individuals.
Seventeen overweight men and women consumed 90 g raisins or isocaloric placebo (264 kcal/day) for 14 days in a randomized, crossover design while following a low-flavonoid diet. The oxidative [urinary 8-iso-prostaglandin-F(2alpha) (8-epi PGF(2alpha)) and serum oxygen radical absorbance capacity (ORAC)], inflammatory (serum C-reactive protein and interleukin-6), endothelial (serum soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1, sVCAM-1) and metabolic [free fatty acids (FFAs), triacylglycerol, glucose and insulin] response to four high-fat (53%) meals was tested pre- and postintervention.
Urinary 8-epi PGF(2alpha) decreased (-22%) and fasting ORAC increased (+3%) after both interventions combined. Fasting protein-free ORAC was modestly (+3.5%) higher during the raisin than the placebo intervention. Neither the meals nor the raisins consistently induced fasted markers of inflammation or endothelial dysfunction. Gender influenced postprandial metabolic responses in that males responded with higher serum FFAs, sVCAM-1 and glucose compared with females.
Serum antioxidant capacity was modestly increased by daily raisin consumption, but this did not alter fasted or postprandial inflammatory response in these relatively healthy but overweight individuals. Providing all food in regular pattern reduced measures of oxidative stress.
氧化应激可引发炎症增加，从而提高心血管疾病风险。本研究的目的是确定超重个体每日食用葡萄干对急性高脂餐后氧化应激、炎症和内皮激活标志物的影响。
17名超重男性和女性采用随机交叉设计，在遵循低黄酮类饮食的同时，食用90克葡萄干或等热量安慰剂（264千卡/天），为期14天。在干预前后测试了对四顿高脂（53%）餐的氧化[尿8-异前列腺素-F（2α）（8-表前列腺素F2α）和血清氧自由基吸收能力（ORAC）]、炎症（血清C反应蛋白和白细胞介素-6）、内皮（血清可溶性细胞间粘附分子-1和可溶性血管细胞粘附分子-1，sVCAM-1）和代谢[游离脂肪酸（FFA）、三酰甘油、葡萄糖和胰岛素]反应。
两种干预措施联合后，尿8-表前列腺素F2α降低（-22%），空腹ORAC增加（+3%）。在食用葡萄干期间，空腹无蛋白ORAC比安慰剂干预时适度升高（+3.5%）。餐食和葡萄干均未持续诱导空腹炎症或内皮功能障碍标志物。性别影响餐后代谢反应，男性餐后血清FFA、sVCAM-1和葡萄糖水平高于女性。
每日食用葡萄干可适度提高血清抗氧化能力，但在这些相对健康但超重的个体中，这并未改变空腹或餐后炎症反应。以规律模式提供所有食物可降低氧化应激指标。
