Spillmann R, Ayala S C, Sanchez C E
Am J Trop Med Hyg. 1976 Jul;25(4):549-51. doi: 10.4269/ajtmh.1976.25.549.
One hundred and fifteen persons with asymptomatic Entamoeba histolytica or E. hartmanni infection, or both, were given metronidazole (750 mg three times daily for 5 days), tinidazole (1 g twice daily on 2 consecutive days), or a starch placebo. Three post-treatment stools were examined in the 2 weeks following initiation of treatment. Cysts of E. histolytica reappeared in the stools of 37% of 30 given metronidazole, 62% of 34 given tinidazole, and 70% of 31 given placebo. Cysts of E. hartmanni reappeared in the stools of 46% of 24 given metronidazole, 69% of 16 given tinidazole, and 90% of 10 given placebo. Rapid absorption and short duration of treatment make both drugs ineffective for the treatment of ameba carriers.
115名无症状溶组织内阿米巴或哈氏内阿米巴感染患者（或两者均有感染）接受了甲硝唑（每日3次，每次750毫克，共5天）、替硝唑（连续2天每日2次，每次1克）或淀粉安慰剂治疗。治疗开始后的2周内检查了3次治疗后的粪便。接受甲硝唑治疗的30名患者中，37%的患者粪便中再次出现溶组织内阿米巴包囊；接受替硝唑治疗的34名患者中，62%出现该情况；接受安慰剂治疗的31名患者中，70%出现该情况。接受甲硝唑治疗的24名患者中，46%的患者粪便中再次出现哈氏内阿米巴包囊；接受替硝唑治疗的16名患者中，69%出现该情况；接受安慰剂治疗的10名患者中，90%出现该情况。药物吸收快且治疗时间短，这使得这两种药物对阿米巴携带者的治疗均无效。
