Islam N, Hasan K
Drugs. 1978;15 Suppl 1:26-9. doi: 10.2165/00003495-197800151-00006.
The efficacy of metronidazole and tinidazole has been compared in 31 patients with hepatic amoebiasis. Only those with unequivocal clinical, radiological and laboratory evidence of hepatic amoebiasis were included; diagnostic and therapeutic aspiration was performed where necessary. 15 patients received metronidazole and 16 tinidazole, in random order. The 2 groups were comparable. Both drugs were given orally in a single daily dose of 2g for a minimum of 3 days, with treatment extended if considered clinically advisable. 12 of 15 patients (80%) were cured with metronidazole given for an average period of 7 days (range 4 to 14 days). 15 of 16 patients (93.8%) given tinidazole were cured and the mean duration of treatment was 4 days (range 3 to 6 days). There were fewer side-effects with tinidazole. In this study of hepatic amoebiasis in Bangladesh, tinidazole was found to be superior to metronidazole in overall efficacy because a shorter course of treatment was necessary and it caused fewer side-effects.
对31例肝阿米巴病患者比较了甲硝唑和替硝唑的疗效。仅纳入那些有明确的肝阿米巴病临床、放射学和实验室证据的患者；必要时进行诊断性和治疗性穿刺。15例患者接受甲硝唑治疗，16例接受替硝唑治疗，顺序随机。两组具有可比性。两种药物均每日口服1次，每次2g，至少服用3天，若临床认为有必要则延长治疗时间。15例接受甲硝唑治疗的患者中有12例（80%）治愈，平均治疗时间为7天（范围4至14天）。16例接受替硝唑治疗的患者中有15例（93.8%）治愈，平均治疗时间为4天（范围3至6天）。替硝唑的副作用较少。在孟加拉国的这项肝阿米巴病研究中，发现替硝唑在总体疗效上优于甲硝唑，因为所需治疗疗程更短且副作用更少。
