Bremond-Gignac D, Donadieu J, Leonardi A, Pouliquen P, Doan S, Chiambarretta F, Montan P, Milazzo S, Hoang-Xuan T, Baudouin C, Aymé S
Service d'Ophtalmologie, Hôpital Robert Debré, APHP, 48 boulevard Sérurier, 75019 Paris, France.
Br J Ophthalmol. 2008 Aug;92(8):1097-102. doi: 10.1136/bjo.2007.117812. Epub 2008 Mar 20.
To determine the prevalence of vernal keratoconjuntivitis (VKC) in Europe.
A cross-sectional survey was mailed to 3003 ophthalmologists from six countries (Finland, France, Italy, The Netherlands, Norway and Sweden) representing 151.9 million inhabitants. Results were analysed per country, and VKC prevalence for the 15 European member states in 2002 was extrapolated. Six hypotheses were used: disease duration (4 or 8 years) combined with three prevalence hypotheses for non-responding ophthalmologists.
The response rate to the survey was 29.5%. The estimates of VKC prevalence in Western Europe (per 10,000 inhabitants) ranged from 1.16 to 10.55. The prevalence of VKC with corneal complications ranged from 0.30 to 2.26. The VKC prevalences per country were in the following ranges: Italy 2.4-27.8, Finland, 0.7-8.4, Sweden 1.2-8.7, The Netherlands 0.6-4.6, France 0.7-3.3 and Norway 0.3-1.9. VKC with corneal complications were: Italy 0.4-4.8, Sweden 0.3-2.4, Finland 0.2-2.8, The Netherlands 0.2-1.6, France 0.3-1.4 and Norway 0.1-1.0.
Based on the most likely hypotheses concerning disease duration and non-responding ophthalmologists' VKC case rate, the best estimate of VKC prevalence in Western Europe is 3.2/10,000 inhabitants. The prevalence of VKC with corneal complications is 0.8/10,000 inhabitants.
确定欧洲春季角结膜炎（VKC）的患病率。
向来自六个国家（芬兰、法国、意大利、荷兰、挪威和瑞典）的3003名眼科医生邮寄了一份横断面调查问卷，这六个国家的居民总数为1.519亿。对每个国家的结果进行了分析，并推算出2002年15个欧洲成员国的VKC患病率。使用了六个假设：疾病持续时间（4年或8年）与针对未回复的眼科医生的三种患病率假设相结合。
调查的回复率为29.5%。西欧VKC患病率（每10000居民）的估计范围为1.16至10.55。伴有角膜并发症的VKC患病率范围为0.30至2.26。每个国家的VKC患病率在以下范围内：意大利2.4 - 27.8，芬兰0.7 - 8.4，瑞典1.2 - 8.7，荷兰0.6 - 4.6，法国0.7 - 3.3，挪威0.3 - 1.9。伴有角膜并发症的VKC患病率为：意大利0.4 - 4.8，瑞典0.3 - 2.4，芬兰0.2 - 2.8，荷兰0.2 - 1.6，法国0.3 - 1.4，挪威0.1 - 1.0。
基于关于疾病持续时间和未回复的眼科医生的VKC病例率的最可能假设，西欧VKC患病率的最佳估计为每10000居民3.2例。伴有角膜并发症的VKC患病率为每10000居民0.8例。
